Improving Value through Evidence-Based Platelet Prescribing

Platelets are a precious resource often in short supply. Children’s Hospital of Philadelphia (CHOP) identified significant variation in prophylactic platelet dosing, creating a multidisciplinary team to safely reduce the standard prophylaxis dose for oncology patients. Supported by education, new evidence-based department guidelines, clinical decision support, and data-driven performance management, they successfully achieved widespread adoption of the dosing guidelines. 


  • 32 percentage point increase in compliance with the new dosing guideline for oncology patients <20kg.
  • 36% increase in whole units transfused, a possible signal of decreased waste.
  • No change in time between transfusions and ED visits after the process change.

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