Modern health care delivery can make a real difference to saving or improving lives. Often, however, those with the greatest needs, and the largest potential gains, have been beyond our reach. We have come to see differences as entrenched and inevitable. The last several years has seen a growing conversation about the importance of health equity. The real challenge, though, is transforming those “grand ideas” into actual change and real, measured, results. This conversation will be a step in that direction – how to start the journey from data and analytics toward achieving the biggest impacts for those with the greatest healthcare needs.